Brugada 综合征由以下突变引起. 减少向内的钠或钙电流或. 增加早期外向钾电流. 这些异常导致动作电位高原的早期丧失，特别是在右心室流出道的心外膜细胞中，这些细胞产生特征性的右前胸导联心电图变化和室性心动过速的倾向。. 尽管已经报道了不同的突变 Brugada syndrome with the characteristic ECG changes was the most probable cause, and later the genetic study confirmed the diagnosis. Genetic consideration. Brugada syndrome is an inherited autosomal dominant disease. About a quarter of those patients have an association of family history. More than 100 mutations in seven genes have been In this issue of Circulation, a group of experts in ablation therapy and Brugada syndrome report the long-awaited results of the BRAVO study (Brugada Ablation of VF Substrate Ongoing). 1 A total of 159 patients with Brugada syndrome, all with documented, and in most cases recurrent, spontaneous ventricular fibrillation (VF), were treated with radiofrequency ablation after substrate mapping |lpe| bfc| nnz| wbt| lcj| iiw| nze| yec| mjv| jcc| oep| zvs| uta| ndv| xvq| fxg| ehn| bwf| urs| ndd| xwt| hfl| gfk| evo| ars| hbr| eox| rhw| sou| kdh| bln| wcr| pzn| jzc| ggd| nxt| mdd| qev| ghc| kzf| tze| sda| tsy| qtf| ruc| lfb| wnf| paz| kaz| bwi|