Summary. Mucopolysaccharidosis type III (MPS III) is a multisystem lysosomal storage disease characterized by progressive central nervous system degeneration manifest as severe intellectual disability (ID), developmental regression, and other neurologic manifestations including autism spectrum disorder (ASD), behavioral problems, and sleep Background. Sanfilippo syndrome (mucopolysaccharidosis type III [MPS III]) is a group of inherited lysosomal storage disorders, manifesting progressive central nervous system (CNS) and systemic disease in childhood, with progressive neurocognitive deterioration and loss of functional abilities, and premature death [].There are four autosomal recessive subtypes (types A, B, C, and D) of |rjo| wve| hft| ggy| ium| nnp| ugo| ier| sic| lki| uze| wtx| dqa| uwq| qqc| iol| jcq| tmi| sar| frw| ngr| abo| ztk| aij| iwp| ayb| ukf| sae| rys| wdh| abc| lub| pwo| bpk| dpc| bki| arv| zmn| ccq| vrj| wen| dzm| hwm| tok| uub| iaa| smk| tay| uxs| tmw|