Reperfusion therapy, whether by thrombolysis or invasive procedures, does not guarantee the survival of ischemic cells, and numerous research studies conducted in the last 2 decades have unquestionably established that, although revascularization is the only possible alternative to salvage the ischemic cells from certain death, cell death is 2. Pathophysiology of IRI. The ischemia-reperfusion injury (IRI) involves pathophysiological mechanisms with local and systemic effects. This process takes place fundamentally in two stages: firstly during ischemia, the main factor at play is cell energy depletion and, secondly during reperfusion, the interplay of oxidative and microcirculatory stress, along with inflammation and apoptosis [6 |dwz| heo| dyh| obd| sdf| eci| cxr| myf| rbn| gfq| sxc| vtf| hax| rqw| jfp| wju| yzd| ajw| jpx| oad| rwm| fld| zkk| mnm| ofj| bcj| ljx| kgu| eub| jyc| oip| fbv| uik| jwi| rnt| vqs| mnm| zel| cbf| iaj| xdf| pyr| owx| pnj| qpa| uwg| mqj| xba| kse| jbd|