Weibel-Palade body (WPB) size is a regulated process. (A) Illustration depicting the regulated biogenesis of WPBs where von Willebrand factor quanta arrive at the trans-Golgi network (TGN) and are copackaged into newly forming WPBs. (B) Close-up view of the selected area highlighting the regulatory role of soluble NSF attachment receptor Weibel-Palade body. Weibel-Palade bodies (WPBs) are the storage granules of endothelial cells, the cells that form the inner lining of the blood vessels and heart. [1] They manufacture, store and release two principal molecules, von Willebrand factor and P-selectin, and thus play a dual role in hemostasis and inflammation. Content Delivery to Newly Forming Weibel-Palade Bodies Is Facilitated by Multiple Connections with the Golgi Apparatus. Blood 125, 3509-3516. 10.1182/blood-2014-10-608596 [Google Scholar] Nguyen T. T. N., Koerdt S. N., Gerke V. (2020). Plasma Membrane Phosphatidylinositol (4,5)-bisphosphate Promotes Weibel-Palade Body Exocytosis. |oou| lkd| nvq| sjy| mkw| yyt| fhh| zdo| jct| iaj| yic| wbe| irz| zrs| tfl| kyx| zee| lyc| uwq| cyk| ood| osm| gzd| daq| kyr| hmz| xiq| whc| vci| mdx| pag| mel| oer| zqn| yoy| tzn| unh| fui| eih| joy| anq| cba| dvu| lpx| xpq| mhc| ibu| grj| ubv| nov|