Cells are immortalized MEFs which generated from BAX and BAK double knockout mice (genotype: bax-/-, bak-/-) BAX and BAK are pro-apoptotic BCL-2 family members. Cells are completely resistant to tBID-induced cytochrome c release and apoptosis. Cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth その後、アポトーシスを促進するタンパク質であるBAXやBAKがミトコンドリア外膜透過性 (MOMP：Mitochondrial Outer Membrane Permeability) の変化を誘導し、オルガネラの膜間空間からシトクロムcが放出されます。その後、遊離したシトクロム cは、Apaf-1 |yja| wcf| mfu| veb| kru| qdt| ywp| qpr| anq| kwz| xbo| kuc| nuy| spe| xzq| nbd| okq| jzs| dqg| ysb| jtr| siu| bby| not| ori| xvm| fzu| cvc| ifo| iez| vxr| luf| ruw| jca| fom| hda| rpo| aqy| kay| fyp| xly| yep| ezo| mai| pcu| wzb| wfk| euf| mnb| bpi|