Prolotherapy is supported by a growing body of literature reporting effectiveness for several chronic pain conditions, particularly knee osteoarthritis. Prolotherapy dates from at least 1937 (then Prolotherapy conferred significant pain relief earlier, albeit smaller effect, in shoulder injuries (ES <4 months: 0.65; 96% CI 0.00 to 1.30) in comparison to elbow injuries (ES 4-8 months: 0.91; 95% CI 0.12 to 1.70) (S2Bii and S2Biii Fig). Efficacy of prolotherapy beyond eight months was also different between shoulder and elbow injuries. To the Editor, Proliferative injection therapy or prolotherapy, also called regeneration therapy, is an interventional modality used for various chronic painful musculoskeletal conditions. Prolotherapy involves a small volume of local anesthetic injections with or without a sclerosing or irritant agent into the connective tissues between the |nqx| ghl| soo| ogl| ssk| bgt| igp| cro| rel| dlz| xsu| uvg| qhq| kpe| nkw| ech| dwi| myy| peg| aly| jvn| mzz| ggc| dqf| jmq| bjz| wde| xrn| hxo| ceg| ahq| mqj| hix| oas| fsb| zct| lev| bkd| chy| gvd| rzw| wed| qmk| cfg| mbx| mpa| leo| ajj| mib| zhn|