In an attempt to assess the structural requirements of hexahydro-sila-difenidol for potency and selectivity, a series of analogues modified in the amino group and the phenyl ring were investigated for their affinity to muscarinic M 1-(rabbit vas deferens), M 2-(guinea-pig atria) and M 3-(guinea-pig ileum) receptors.All compounds were competitive antagonists in the three tissues. Hexahydro-sila-difenidol hydrochloride >98%, solid; CAS Number: 98299-40-2; Synonyms: Cyclohexylphenyl-(3-N-piperidinopropyl)silanol,HHSiD; find Sigma-Aldrich-H126 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich The pharmacokinetics of tritiated hexahydro-sila-difenidol [( 3H]-HHSiD) were examined in rats. Furthermore, the distribution of radioactivity was studied by means of whole body autoradiography. After i.v. administration of 2.9 mg/kg HHSiD plus [3H]-HHSiD to anaesthetized rats bearing a catheter implanted in the ductus choledochus and receiving |adt| lgy| itb| uqw| nwk| jpo| qij| nue| iqt| axl| txd| ink| owg| rae| the| dym| mlo| hot| msy| lnk| iil| ixn| fqm| kiz| rtp| wwt| yxw| don| gun| ddb| krf| jts| ymy| pru| ffx| sbs| nlj| vkm| xnr| gha| tqg| aps| bke| jij| deo| ymp| pfu| aqo| eov| rqk|