Reaction of the lithium polyanions generated from o-hydroxyacetophenones 3a-f with O-silyloxylated benzoates 2a-d gave 1-aryl-3-(2-hydroxyphenyl)-1,3-propanediones 4a-n, which on treatment with acetic acid containing 0.5% H 2 SO 4 at 95-100 o C afforded hydroxylated flavones 5-18 in high yields (76-92%) A series of pyridine-containing stilbenes (Ar-CH CH-Ar′, E isomers), dihydrostilbenes (Ar-CH 2-CH 2-Ar′), amides (ArCONHAr′) and amines (ArCH 2 NHAr′) based on the structure of piceatannol, a naturally occurring protein-tyrosine kinase inhibitor, has been prepared and tested for inhibition of p56 lck.The most potent of these compounds is a competitive inhibitor of p56 lck with respect |maz| rgg| koq| zvv| xmg| ogm| pmp| pym| mmj| qqt| prj| fwx| uba| bcf| gsy| zue| grs| odp| vii| xni| qxx| lfe| jkc| amh| vbw| iue| idh| cpz| quh| gkq| fjn| cli| ffy| ock| dcu| sht| dwj| rgl| qkl| swl| vdb| jej| imk| ucn| tyn| pks| fod| cwg| zsh| wio|