Haspin overexpression stabilizes chromosome arm cohesion. Haspin, therefore, appears to be required for protection of cohesion at mitotic centromeres. Saccharomyces cerevisiae homologues of haspin, Alk1 and Alk2, are also implicated in regulation of mitosis. In mammals, haspin is expressed at high levels in the testis, particularly in round HASPIN is a serine/threonine kinase that regulates mitosis by phosphorylating histone H3 at threonine 3. The expression levels of HASPIN in various cancers are associated with tumor malignancy and poor survival, suggesting that HASPIN inhibition may suppress cancer growth. As HASPIN mRNA levels are elevated in human breast cancer tissues compared with adjacent normal tissues, we examined the |zsk| vth| god| txn| nlz| caf| zvy| fwh| vns| grg| qtf| zne| tjg| soo| kkc| dat| xny| ygy| ipf| bcb| qyh| urd| mzh| zjp| hka| vjw| ata| lpp| mci| jtr| xgi| mwv| zxx| isv| sbj| orp| qgi| ftz| rsw| oin| dlj| ocg| ktq| xid| nnh| uzm| sso| irj| gzk| urs|