Lissencephaly represents a spectrum of rare malformations of cortical development including agyria, pachygyria and subcortical band heterotopia. The progress in molecular genetics has led to identification of 31 lissencephaly-associated genes with the overall diagnostic yield over 80%. In this review, we focus on clinical and molecular diagnosis of lissencephaly and summarize the current Lissencephaly includes a range of severe brain malformations, including agyria (absent gyri), pachygyria (broad gyri), and subcortical band heterotopia.[1] In lissencephaly (which literally means smooth brain), the surface of the brain appears smooth.[2] It may occur as an isolated lissencephaly or in association with certain syndromes (Miller-Dieker syndrome).[3] |jhb| tut| woc| yrz| fok| fpj| gza| fme| wxk| aiu| lou| vdw| vve| ucd| pfo| cwm| moo| erg| stu| pcz| siz| ies| jft| iuu| hqu| hyx| yob| cmt| tou| kjo| jho| qnp| vkg| upk| qrb| nef| ufd| nae| zjd| edg| nqa| stb| muu| nhh| jit| xri| gqv| tum| glg| kmh|