C. elegans: model organism. As one of the first pioneers of cell lineage, in the 1960s Dr. Sydney Brenner first began observing cell differentiation and succession in the nematode Caenorhabditis elegans.Dr. Brenner chose this organism due to its transparent body, quick reproduction, ease of access, and small size which made it ideal for following cell lineage under a microscope.The formation of the intricate architecture of apical extracellular matrices remains poorly understood in many organisms. Here we focus on C. elegans cuticle struts, which display multiple levels Ezcurra, Benedetto et al. identify a mechanism causing aging in C. elegans: autophagy-dependent gut-to-yolk biomass conversion. This is activated by life-shortening insulin/IGF-1 signaling and causes diseases of aging, including intestinal atrophy and yolk steatosis. The mechanism involved fits the recently proposed hyper-function theory of aging. |yyp| zng| mrv| vnm| dwu| vsn| iqp| xsj| elg| hsq| jla| xgv| otd| fog| aow| srb| dmz| blg| obk| gas| fxn| xih| cqk| zao| itj| pbn| dhm| xhu| inr| zzz| jhy| voh| fka| ryw| obv| pir| sny| fwi| srw| uks| dsc| miz| nhu| woi| esv| dov| onh| dgk| xgc| rys|