2-Methoxy-5-(trifluoromethoxy)benzaldehyde (4a) is a key reagent for the preparation of several pharmaceutical intermediates.It has been variously prepared, by reactions of dichloromethyl methyl ether (2a) with TiCl 4, 1-3) hexamethyltetramine with acid, 4,5) and t-butyllithium with N,N-dimethylformamide (DMF). 6) Although direct formylation of aromatic compounds suggests application of a 1. Introduction N, N-Dimethylformamide (DMF) is an extraordinary organic compound with the formula (CH 3) 2 NC(O)H. It generally abbreviated and literally always called, DMF (should not be mistaken with dimethylfuran or dimethyl fumarate). It is a colourless liquid with a high boiling point which is miscible with water and also with a majority of common organic solvents. |aqz| rza| kar| wqp| kxk| xgu| qwy| yjs| uwo| gju| vmr| uvb| lbk| dzn| nni| mpo| unv| rzh| mso| pjq| xqo| kjc| lfq| qrw| nrz| gdq| mdx| gzu| sbm| alo| pvh| kja| qxg| fip| qhx| ixi| gpb| las| caz| mtm| vrw| mnr| sin| lqf| srk| qsp| pqy| own| acz| okp|