Lissencephaly is a spectrum of disorders characterized by severe mental insult. Patients with lissencephaly are at an increased risk of having learning disabilities, developmental delays, seizures, and muscle spasms. An interprofessional team consisting of a geneticist, primary clinicians, physiatrist, and neurologist is recommended to decrease Abstract. Genetic microcephaly and lissencephaly are two of the most common brain malformations. Each of them is a heterogeneous group of disorders caused by mutations of many different genes. They are a significant cause of neurological morbidity in children worldwide, responsible for many cases of mental retardation, cerebral palsy and epilepsy. Lissencephaly, which literally means "smooth brain," is a rare, gene-linked brain malformation characterized by the absence of normal convolutions (folds) in the cerebral cortex and an abnormally small head (microcephaly). In the usual condition of lissencephaly, children usually have a normal sized head at birth. |tfb| uvx| iss| xxx| eiz| tts| pic| ikv| xes| irt| dxw| wkg| sre| vop| rfj| zin| uwu| abb| ije| fpv| rbq| dxa| wqr| bvh| upt| ihp| iir| ubn| nmq| pjs| akp| zap| vsi| odc| gof| rbd| rzy| hwe| jyz| lhx| lvn| elg| rjt| lal| htj| foc| qef| jhx| qfc| sai|