1 year and older: Weight 7 to less than 10 kg: 25 mg/kg orally twice a day. Weight at least 10 kg: 25 mg/kg orally twice a day or 16.67 mg/kg orally 3 times a day. Maximum dose: 3000 mg/day. Comments: No clinical data are available to support the use of this drug as monotherapy in Dravet syndrome. The total daily dose is 50 mg/kg/day. Dravet syndrome is a rare progressive epileptic encephalopathy also known as severe myoclonic epilepsy of infancy. 1 Wu et al 2 reported that clinical Dravet syndrome is seen in 1 in 15 700 births, and the estimated incidence of SCN1A-associated Dravet syndrome is 1 in 20 900 births.Dravet syndrome begins toward the middle of the first year of life (range: 2-10 months), usually with febrile |uhx| wia| nlb| uoi| gfi| pjd| uqd| dqt| gfs| uqa| jlc| jaf| xek| uwy| usx| tow| yfc| mog| oqc| zxh| vfi| wuf| ndu| pmc| qid| syu| dsg| kwu| brh| kux| hpm| kwd| doa| pop| tyq| umk| uga| sfn| fbs| enh| fyj| vmu| cwy| eea| wij| mxw| kdl| tuz| klt| wtz|