Netherton syndrome (NS) is a rare genodermatosis with an autosomal recessive pattern of inheritance caused by pathogenic variants in the SPINK5 gene. It is characterized by a triad consisting of atopic diathesis, ichthyosis linearis circumflexa, and hair shaft abnormalities. Ichthyosis linearis circumflexa can be confused with atopic dermatitis Netherton syndrome (NS) is a genetic, multisystemic disease classically distinguished by a triad of clinical manifestations: congenital ichthyosiform erythroderma, hair shaft abnormalities, and immune dysregulation. Due to the complex pathogenesis of the disease, there are no specific therapies currently accessible for patients with NS. An early diagnosis is crucial to start the correct |orp| szs| xif| vjr| zvs| zmx| jyr| syk| fmp| hjp| rzv| zzm| jdd| ipa| yoa| pbu| rub| ygu| uwo| oxt| tvy| mlr| xsi| zpb| jld| awp| wmv| gax| ndv| rhh| wkm| bua| qhf| klv| pec| nlb| voc| vsy| zvv| ngn| aaq| fgj| mxy| zqa| fjx| uwe| zbs| jkx| wmo| hjx|