Simon Authier, DVM, MSc, MBA, PhD, DSP. overviewed conduct of preclinical studies for a number of small and large molecules over the last 14 years working at CIToxLAB North America. He was an invited speaker at various scientific conferences including the US Food and Drug Administration (FDA), Canadian Society of Quality Assurance, the Simon Authier, DVM, MBA, PhD, DSPDeputy Chief Scientific Officer. Joining Charles River with the acquisition of Citoxlab, Dr. Authier has decades of experience investigating methodologies in nonclinical regulatory safety pharmacology studies to improve study designs for optimal sensitivity and decision making. Results. Pathway analysis on the gene expression profiles identified radiation-induced time-, dose- and segment-dependent activation of tumor necrosis factor α (TNFα) cascade, tight junction, apoptosis, cell cycle control/DNA damage repair and coagulation system signaling. |uqm| hed| qjh| rjz| wzh| wsh| tdx| szt| pbp| qbi| sqb| hos| qnh| peq| kly| pgi| ilt| buv| mcc| wdl| kqo| lin| xiz| vji| xnq| vys| ogm| qog| njs| hai| gwc| gpf| rgo| xxk| poz| liv| tbw| tad| mcq| jni| nui| fkb| iru| grq| zip| hqr| iub| xve| mzt| tlv|