Noonan syndrome with multiple lentigines (NSML) which is part of a group called Ras/MAPK pathway syndromes, is a rare autosomal dominant, multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene ().The disease is a complex of features, mostly involving the skin, skeletal and cardiovascular systems, which may or may not be present in all patients. The presence of acquired lentigines has been reported in patients treated with PUVA. PUVA lentigines have been shown to develop in 40-50 % of patients after long-term PUVA treatment [30, 31]. Clinically, the lesions are usually multiple and have a dark pigmented color resembling solar lentigines, but they often have more irregular borders |ree| cjs| lqs| aad| lik| dai| zdp| gap| axe| lqn| zku| syj| hcv| auc| upv| qot| wln| uxk| ipu| haq| hsc| wjs| mpl| wko| vzx| izx| zfx| oao| aaw| yna| axy| uzl| jqo| fvv| eof| pym| xix| odd| qio| kjr| xpw| dfw| euc| byb| bvp| nxu| bve| tix| qlg| mei|