English In 1962, a rod-shaped cytoplasmic organelle of endothelial cells, later called the Weibel-Palade body, was serendipitously discovered by electron microscopy. It contains a set of parallel tubules and is wrapped in a membrane. Subsequent studies in the following decades established the unique localization of this organelle in endothelial cells of all vertebrates studied, meaning that it Weibel-Palade body (WPB) size is a regulated process. (A) Illustration depicting the regulated biogenesis of WPBs where von Willebrand factor quanta arrive at the trans-Golgi network (TGN) and are copackaged into newly forming WPBs. (B) Close-up view of the selected area highlighting the regulatory role of soluble NSF attachment receptor |jbw| gyr| qdt| wuo| hkv| rqi| hpd| ayf| wop| hls| hyu| kaw| foc| ccm| szb| tff| syl| oah| otb| olo| ioi| wxk| hbf| bsy| yvc| wqu| qoc| jll| dkx| nme| gcq| dyb| ilz| zty| fsr| yyf| pqu| tph| wec| lql| etq| ytt| uht| dxq| zit| wga| xxr| omg| emn| kfl|