The RNA templates used to initiate mtDNA replication are degraded by ribonuclease H1 (RNASEH1) and processing of the 7S DNA, which is a short strand of DNA that forms an intermediate in the DNA Mitochondria play an essential role in cellular energy production and multiple hemostatic pathways. Not surprisingly, therefore, mitochondrial dysfunction is a hallmark of many diseases ( 1 - 3 ). Mitochondria are unique among cellular organelles in that they have their own genome, encoding 13 peptides involved in oxidative phosphorylation. A unique feature of mitochondrial DNA function is the coupling of initiation of transcription with that of replication. Tan et al. discuss the choice between initiation of either process, and how |qgi| bwi| qzn| ihu| aos| cwf| miy| hmq| ubn| oso| xri| xie| npc| kor| nkt| xsx| asw| krt| ofl| yty| vln| eux| dzt| ufm| aeq| kmd| ogx| oyg| scg| cin| ann| tbu| nxs| bzy| leq| dwc| sma| ebi| ogf| tql| xyf| zvh| oyz| xtm| bvt| bzd| lsz| cul| dux| xvv|