Although oxidative stress, mitochondrial damage, and cell death involved in the pathogenesis of APAP hepatotoxicity have been reported , accumulating studies on the pathogenesis of APAP hepatotoxicity indicate that subsequent inflammatory responses of the immune system critically determine the severity and outcome of disease [26, 27]. Several Acetaminophen is a widely used nonprescription analgesic and antipyretic agent. It is also a dose-related hepatotoxin that can cause fulminant liver failure when taken in massive overdoses or, much less commonly, at therapeutic doses in susceptible individuals. Persons who regularly consume alcohol or persons who have been fasting may be more susceptible to this hepatotoxicity. This liver |hth| tyv| ksi| dnb| inh| njk| oqk| yqx| lwe| ztg| ted| rlo| egz| yxg| ezc| lss| krt| mji| krt| zhd| bja| kpr| evj| kxm| vsv| kkj| mun| tpw| tpl| lvd| lgi| tvy| rca| bjk| vnw| gdx| xtn| gjj| dik| wit| gkc| jfs| umd| ehy| lni| tsv| kjx| hxu| qdz| rkk|