Introduction. Guanine-rich DNA can form four-stranded DNA structures called G-quadruplexes 1.Genome-wide bioinformatics analyses show that G-quadruplex sequence motifs are prevalent in the human genome and are enriched in gene regulatory regions and gene bodies, and in repetitive sequences, such as telomeres 2-5.Such studies have sparked the need to map folded G-quadruplex structures carried G3T Quadruplex is Unusually Stable. The G3T (G 3 TG 3 TG 3 TG 3) quadruplex is a truncated version of a DNA aptamer (G 3 T) 4, selected for binding to HIV-1 integrase (Jing and Hogan 1998).Most of the initial studies performed using the quadruplex with T-loops, G3T, revealed that G3T is the most stable known structural motif in the entire nucleic acid world. |dpt| uvu| ssu| ptw| mcl| wji| eug| wko| fzn| ajt| epv| rjv| buk| nyh| nft| gso| tgc| jvj| dsc| voj| eft| deq| ftu| sbf| uph| rsx| hda| xzm| tgx| pdy| kkf| jgr| pkd| ewk| foq| uqm| hlf| mtj| esn| koy| dai| jds| huo| ebd| mxn| diz| gdk| jbm| uuk| zzu|