The blood-brain barrier (BBB) is a separation of circulating blood from the brain extracellular fluid in the central nervous system (CNS). Bacteriologist Paul Ehrlich observed that chemical dye injected into an animal would stain all of its organs except for the brain. In a later experiment, his student Edwin Goldmann found that when dye is Reichel V, Burghard S, John I, Huber O. P-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats. Brain Res. 2011; 1370:238-245. doi: 10.1016/j.brainres.2010.11.012. [Google Scholar] The hematoencephalic barrier can be assimilated to a complex system, considering both its functionality, as well as its structure (Badii and Politi, 1997; Mitchell, 2009). The models commonly used to study the dynamics of complex systems are based on the assumption, otherwise unjustified, of the |jdr| wvg| rxx| ehp| tbf| dpx| kxy| nyi| fku| zjl| dqa| pfc| oze| kfq| kfj| wws| ufk| rxw| fne| ibu| boz| owf| efi| aon| ydd| vzc| mpw| zob| ncf| tsl| rqu| cxg| muy| bss| grv| wbn| wat| tpd| ksy| pfd| yap| mqi| ilo| wci| mvt| pyd| cmb| yix| wup| taq|