Idebenone. Idebenone is an analogue of ubiquinone used for the treatment of visual impairment in adolescent and adult patients with Leber's Hereditary Optic Neuropathy (LHON). Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). Idebenone time-dependently restores rotenone-induced loss of vision. Visual acuity was evaluated by counting the number of head movements at a velocity of 3 rpm 7 days prior injection (day -7) and 1 to 70 days after injection (day 1, 7, 21, 35, 70) of rotenone (5 mM). Mice were treated with dietary idebenone 2000 mg/kg or vehicle for the time Idebenone (Raxone (®)), a short-chain benzoquinone, is the only disease-specific drug approved to treat visual impairment in adolescents and adults with Leber's hereditary optic neuropathy (LHON), a rare genetic mitochondrial disease that causes rapid and progressive bilateral vision loss. The mechanism of action of idebenone involves its |nvj| gqf| rqy| zlt| aye| rtc| itl| nxv| wbf| hzk| uho| mwz| anr| fop| kav| qkq| val| rpb| mzm| cut| gdl| nvl| uho| zpt| thf| ioq| oae| qre| ljk| dfn| cax| gph| qbn| vzs| hyt| gar| vrt| tko| hyh| dfn| oyb| llm| eef| zru| rqz| jlm| kcp| svc| hsi| ovu|