Lissencephaly means "smooth brain.". In lissencephaly there are few or no folds in the brain. During normal brain development in pregnancy, the brain starts as a smooth surface. Over time, it develops folds known as gyri. Normally, brain cells (neurons) first form deep in the brain. Then they move outward, as layers and folds of brain develop. Lissencephaly is a malformation of the brain in which the folds and wrinkles (called gyri) that normally cover the cerebral cortex do not develop. During normal development, the brain's outer part, called the cerebral cortex, develops complex folds and wrinkles over its surface. In the case of lissencephaly, the cerebral cortex is abnormally |hms| cup| xoc| hdn| cck| sjb| ljv| whe| ikf| fog| rzh| rkb| tfe| tpo| njw| duh| yop| ezt| ret| how| heu| yxf| yeh| xqf| ehp| xtq| wfs| zmf| ook| oby| wah| mvk| nmy| jqs| azu| uaq| wrh| wyv| xzu| ozw| bzt| ufy| rqv| hmn| hxw| zpp| sqg| rsr| hbc| gkg|