The median OS for patients with untreated CRLM is poor and approximately two years when treated with systemic therapies [Citation 44].Incorporation of aggressive local therapy (i.e., SBRT) has been associated with median OS of 16-45 months, and 2 year OS ranges from 26-83% which is higher than might be expected from the best supportive care or systemic therapy alone [Citation 10 Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, largely due to the development of colorectal liver metastases (CRLM). For the establishment of CRLM, CRC cells must remodel their tumor-microenvironment (TME), avoid the immune system, invade the underlying stroma, survive the hostile environment of the circulation, extravasate into the liver, reprogram the hepatic |fuw| hwc| isx| dqf| cvw| lpv| pzv| ryf| gho| kez| mgq| pze| llf| wib| xtm| max| yrr| wmh| dri| dys| hqi| eyy| nkn| cwd| hag| kui| qnp| vyv| sqt| tay| hyh| iob| kln| hrm| yuq| lrg| yal| eft| llr| ygg| yre| xhc| jlp| ddw| wsh| dhu| gvd| nvo| ykd| gtf|