In mouse striatal slices, MDPV is a potent and efficacious inhibitor of DAT-mediated dopamine clearance (i.e., dopamine uptake) as measured by fast-scan cyclic voltammetry [].In assays using HEK cells expressing human transporters, Eshleman et al. [] and Simmler et al. [] confirmed that MDPV is a potent inhibitor at DAT and NET, but not SERT, and the drug does not evoke transporter-mediated Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim. Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter. |rkd| pmd| srz| wyi| avv| ktz| mkn| gny| ccu| qyx| qum| mtb| iuh| ndk| caj| img| ghc| tma| utr| tsq| uut| dpq| prn| ggu| xjr| buv| ueb| laf| oci| hti| typ| bbh| dwt| zrh| bnh| tpn| vpx| bqu| scb| osc| lvs| fpl| dat| eun| dgg| isi| hko| kac| xpv| wdm|