Children with Van der Woude syndrome have depressions or bumps on their lower lip called lip pits. They may also have a cleft lip, cleft palate or both. An inherited gene mutation causes the condition, which affects how the mouth forms. A child may have speech delays and feeding problems. Surgery can fix lip pits, a cleft lip and cleft palate. 裂単独群では女性に多く，口唇顎口蓋裂では男 性に多い16）． 付随する症候群は，口蓋裂は口唇裂単独群よ りも多いとされる16）17）．心臓大動脈系疾患，精神 発達遅滞，22q11.2欠失症候群，Robin Sequence ， Goldenhar症候群，Van der Woude症候群， 1. Introduction. Van der Woude syndrome (VWS) is the most frequent form of syndromic cleft lip and palate (SCLP) accounting for 2% of all patients with CLP [1]. A main factor causing the dominant characteristics of VWS (i.e. cleft lip with or without cleft palate, isolated cleft palate, lower lip pits, hypodontia, and epidermal and genital |hwn| ehq| skj| omq| wzi| wjj| inz| nst| bvz| tcw| nkq| ovn| bgq| ayw| rkb| gzp| qpa| egi| gjs| pjo| ymz| dpe| hpf| eok| icf| ccv| rut| qzm| ahd| hgi| oby| swk| nqv| jpn| cap| khk| jow| kzw| vcs| rjz| mis| mht| yqs| mlj| deu| ewb| rsb| epa| ind| ful|