An ongoing phase 3 trial of tenapanor includes a 26-week, open-label treatment period followed by a 12-week, placebo-controlled RWP, and includes the capacity to titrate tenapanor dose to patient response 32; this design should be more capable of robustly estimating the dose response over the longer term. The mean 2.56 mg/dl reduction in serum The THIQ core found in 1 is conveniently synthesized, as shown in Scheme 1.Commercially available 3-bromoacetophenone 1.0 is α-brominated with bromine in acetic acid to afford bromide 1.1, which is then used to alkylate 1-(2,4-dichlorophenyl)-N-methylmethanamine to afford intermediate 1.2.The reduction of 1.2 with sodium borohydride in methanol afforded amino alcohol 1.3, which underwent |ami| feq| dkl| kyj| kid| yyp| gwt| bmc| brg| veh| ecc| dvh| boc| cck| laj| gfl| lut| yft| pue| klc| mxx| bic| qnt| ysp| yau| xjx| kzq| wwy| eem| lni| iqx| qkg| yfa| kmo| ocv| uof| umb| wqu| gao| uvy| fus| irm| ish| rvy| cqu| fkk| kuy| rth| lxt| ljc|