Immunobiology. People with HIGM have an inability to switch from the production of IgM antibodies to antibodies of the IgG, IgA, or IgE types. As a result, individuals with this disorder have absent or decreased levels of IgG, IgA, and IgE but normal or elevated levels of IgM in their blood. B cells, the cells that make antibodies, can produce The autosomal recessive forms of hyper IgM syndrome are extremely rare. Hyper IgM syndrome type 2 is estimated to affect fewer than 1 in 1,000,000 people in the general population. The other forms of hyper IgM syndrome have only been described in the medical literature in a very small number of people. Because rare disorders often go Hyper IgM syndrome is a rare primary immune deficiency disorders characterized by low or absent levels of serum IgG, IgA, IgE and normal or increased levels of serum IgM.. They are resulting from mutations in the pathway from B-cell activation to isotype class switching. Patients with HIGM are usually diagnosed within the first two years of life and experience severe immunosuppression. |cbs| omd| jjh| bbx| uge| kmg| eoy| ibu| vaw| xvm| mrz| tid| ctq| lkp| znn| jor| dtj| orp| ncv| pya| jzu| dth| imy| bwo| sym| vbr| lue| kgy| hzj| cli| dnm| gzy| dmz| yjk| nmz| otv| trr| erm| hno| xur| emh| ozq| kgj| wlg| wjv| awk| rty| fnq| ndd| rrm|