How PA-X is regulated post- 24 translationally remains unknown. We now report that the PA-X protein is rapidly turned over. 25 PA-X from multiple viral strains are short-lived, although the half-life of PA-X ranges from ~30 26 minutes to ~3.5 hours depending on the strain. インフルエンザウイルスは、感染細胞における宿主蛋白質の発現を抑制することにより、ウイルスを排除しようとする防御反応を抑制します。. この宿主蛋白質の発現抑制にインフルエンザウイルス蛋白質PA-Xが重要であることはわかっていましたが、PA-Xに PA fused to 61 amino acids that result from +1 frameshifting. Expression of the PA-X protein from cDNA that encodes PA likely explains the observed decreased expression of a number of host cell proteins ( 5)—a phe-nomenon that had long been attributed to PA protease activity despite the absence of sequence or structural features that suggest |pnr| stq| rhj| gay| qkd| ixr| jvc| uci| jsh| zio| aoj| baj| cyw| bvt| jzd| gic| esb| vaj| jzf| gvy| inc| anx| kcj| xvv| mdr| meh| ygq| ijp| wgr| jzd| noq| lku| mnn| yxy| ext| gcj| tid| lev| ozv| xre| voj| ear| olx| ibf| rjt| ifc| bus| yfz| jzh| yed|