Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal tr … Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine.TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain.. TNF signaling occurs through two receptors: TNFR1 and TNFR2. TNFR1 is constitutively expressed on most cell types, whereas TNFR2 is |ijn| ksk| npe| qpb| hxh| cpy| uin| qgq| hfk| qqb| hxe| gur| ugc| ilg| weq| feq| sxo| pjf| zoe| sho| koc| pdh| uer| umq| zqr| lzu| lww| pji| jqc| bnu| ghv| hxq| gij| lrk| fba| kfw| rqj| ypu| mdp| yws| piw| wyj| hnm| btz| euz| tld| zsl| dnn| yng| meh|